State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, PO Box 98, No. 15 BEISANHUAN East Road, Beijing 100029, P. R. China.
Chem Commun (Camb). 2012 Oct 25;48(83):10349-51. doi: 10.1039/c2cc35110b.
Highly efficient and enantioselective asymmetric Henry-Michael one-pot reaction has been achieved on bifunctional heterogeneous catalysts with inherent achiral hydroxyls as acidic sites and immobilized chiral amines as basic sites. Final products were afforded in yields of up to 85% and ee of 99%.
在具有固有手性羟基的非均相双功能催化剂上，实现了高效和对映选择性不对称 Henry-Michael 一锅反应，其中手性伯胺作为碱性位点固定在催化剂上。最终产物的产率高达 85%，对映体过量值（ee）高达 99%。
