The Academic Unit of Child and Adolescent Psychiatry, Imperial Collage London (St Mary's Campus), Norfolk Place, London, W2 1PGUK, UK.
Soc Psychiatry Psychiatr Epidemiol. 2013 May;48(5):735-44. doi: 10.1007/s00127-012-0572-z. Epub 2012 Sep 16.
The nature of adolescent sub-syndromal depression has not been investigated in primary care.
To document frequency, characteristics and 6 month outcome of sub-syndromal depression amongst adolescent primary care attenders.
Primary care attenders (13-18 years) completed depression screening questionnaires (Mood and Feelings Questionnaires) at consultation and at 6 month follow-up. Those screening positive were interviewed with the K-SADS. Sub-syndromal depression was defined as high levels of depressive symptoms in the absence of depressive disorder.
Two hundred and seventy four questionnaires were completed at consultation: the estimated rate of sub-syndromal depression was 25 %. These young people were clinically intermediary between those without depressive symptoms and those with depressive disorder; at 6-months follow-up 57 % had persistent depressive symptoms and 12 % had developed a depressive disorder. Negative life events during the follow-up period and a positive family history of depression were the strongest predictors of symptom persistence and the development of depressive disorder, respectively.
Sub-syndromal depression is common and persistent, in adolescent primary care attenders and it deserves attention.
青少年亚综合征性抑郁的性质尚未在初级保健中进行研究。
记录青少年初级保健就诊者亚综合征性抑郁的频率、特征和 6 个月的结局。
初级保健就诊者（13-18 岁）在就诊时和 6 个月随访时完成抑郁筛查问卷（情绪和感受问卷）。那些筛查阳性的人使用 K-SADS 进行访谈。亚综合征性抑郁的定义为抑郁症状水平高，但不存在抑郁障碍。
有 274 份问卷在就诊时完成：亚综合征性抑郁的估计发生率为 25%。这些年轻人在临床介于无抑郁症状和抑郁障碍之间；在 6 个月的随访中，57%的人持续有抑郁症状，12%的人发展为抑郁障碍。随访期间的负性生活事件和抑郁家族史阳性分别是症状持续存在和发展为抑郁障碍的最强预测因素。
青少年初级保健就诊者中，亚综合征性抑郁很常见且持续存在，值得关注。
