丙二醇可增强保泰松的抗炎作用。

Propylene glycol enhances anti-inflammatory effects of phenylbutazone.

Oshiro T T, Teixeira C F, Oga S

Departamento de Farmacologia, Universidade de São Paulo, Brazil.

Gen Pharmacol. 1990;21(1):131-4. doi: 10.1016/0306-3623(90)90608-o.

Abstract

The interference of propylene glycol with anti-inflammatory effects of phenylbutazone was investigated. 2. Inhibitory effect of phenylbutazone on both carrageenin-induced edema and the cotton pellet granuloma was increased when propylene glycol was used as solvent. 3. Propylene glycol given alone inhibited carrageenin-induced edema and pleurisy, as well as granulomatous tissue formation. 4. Some pharmacokinetic parameters of phenylbutazone were also changed by propylene glycol administered simultaneously. 5. These results suggest that propylene glycol probably increases the anti-inflammatory effect of phenylbutazone by summation and by raising the plasma half-life and the distribution volume of phenylbutazone.

摘要

研究了丙二醇对保泰松抗炎作用的干扰。2. 当丙二醇用作溶剂时，保泰松对角叉菜胶诱导的水肿和棉球肉芽肿的抑制作用增强。3. 单独给予丙二醇可抑制角叉菜胶诱导的水肿和胸膜炎以及肉芽肿组织形成。4. 同时给予丙二醇也改变了保泰松的一些药代动力学参数。5. 这些结果表明，丙二醇可能通过累加作用以及延长保泰松的血浆半衰期和分布容积来增强保泰松的抗炎作用。