Grau M, Guasch J, Montero J L, Felipe A, Carrasco E, Juliá S
Department of Pharmacology and Toxicology, Prodesfarma Research Center, Barcelona, Spain.
Arzneimittelforschung. 1991 Dec;41(12):1265-76.
Aceclofenac (2-[(2,6-dichlorophenyl) amine]phenylacetoxyacetic acid; CAS 89796-99-6) is a new orally effective non-steroidal anti-inflammatory agent of the phenylacetic acid group which showed remarkable anti-inflammatory, analgesic, and antipyretic properties. Hence, aceclofenac possesses a potent inhibitory activity in several models of acute and chronic inflammation in rodents, and resembles indometacin and diclofenac in its pharmacodynamic profile, being superior to naproxen and phenylbutazone. In addition, aceclofenac was found to be highly active against sodium urate-induced synovitis in dogs and adjuvant-induced polyarthritis in rats, both prophylactically and therapeutically. The analgesic effect of aceclofenac on the pain elicited by chemical and mechanical stimuli was nearly equal to or slightly better than that of indometacin and diclofenac. Fever induced by brewer's yeast injection in rats was also markedly suppressed by aceclofenac. In contrast, the acute gastric ulcerogenic activity of aceclofenac was about 2, 4 and 7-fold lesser than that of naproxen, diclofenac, or indometacin, respectively. As a consequence of its high anti-inflammatory activity and lower potential for gastric damage aceclofenac exhibited the most favourable therapeutic ratio in comparison with indometacin, diclofenac, naproxen, and phenylbutazone. These data indicate that aceclofenac could be a potent anti-inflammatory and analgesic agent with a wide margin of safety in clinical practice.
醋氯芬酸（2-[(2,6-二氯苯基)氨基]苯乙酰氧基乙酸；CAS 89796-99-6）是一种新型口服有效的苯乙酸类非甾体抗炎药，具有显著的抗炎、镇痛和解热特性。因此，醋氯芬酸在多种啮齿动物急慢性炎症模型中具有强大的抑制活性，其药效学特征与吲哚美辛和双氯芬酸相似，优于萘普生和保泰松。此外，已发现醋氯芬酸在预防和治疗方面对犬尿酸钠诱导的滑膜炎和大鼠佐剂性多关节炎均具有高度活性。醋氯芬酸对化学和机械刺激引起的疼痛的镇痛作用几乎与吲哚美辛和双氯芬酸相当或略优。醋氯芬酸也能显著抑制大鼠注射啤酒酵母诱导的发热。相比之下，醋氯芬酸的急性致胃溃疡活性分别比萘普生、双氯芬酸或吲哚美辛低约2倍、4倍和7倍。由于其高抗炎活性和较低的胃损伤可能性，与吲哚美辛、双氯芬酸、萘普生和保泰松相比，醋氯芬酸表现出最有利的治疗比率。这些数据表明，醋氯芬酸在临床实践中可能是一种具有广泛安全范围的强效抗炎和镇痛药。
