Doursout M F, Chelly J E, Wouters P, Lawrence C, Liang Y Y, Buckley J P
Department of Anesthesiology, University of Texas Medical School, Houston.
Hypertension. 1990 Feb;15(2 Suppl):I117-20. doi: 10.1161/01.hyp.15.2_suppl.i117.
This study was designed to investigate the relation between gender, an endogenous inhibitor of the Na+-K+ pump, and volume-dependent hypertension induced by stimulation of the brain renin-angiotensin system and increased salt intake. Angiotensin II (20 ng/min i.c.v.) was infused for 4 weeks in five dogs of each sex with saline as the drinking fluid. In male dogs, angiotensin II induced parallel pressor (30%) and dipsogenic responses (70%), whereas no hypertension and no increase in fluid intake were observed in females. In contrast, the activity of the Na+-K+ pump as assessed by 86Rb uptake was independent of gender. Our data provide novel evidence that gender plays a determining role in the physiological properties of centrally administered angiotensin II.
本研究旨在调查性别、钠钾泵的内源性抑制剂与脑肾素-血管紧张素系统刺激及盐摄入量增加所诱导的容量依赖性高血压之间的关系。以生理盐水作为饮用水，对每组五只雄性和雌性犬持续4周脑室内输注血管紧张素II（20 ng/min）。在雄性犬中，血管紧张素II引起了平行的升压反应（30%）和饮水增多反应（70%），而雌性犬未出现高血压和饮水量增加的情况。相比之下，通过铷-86摄取评估的钠钾泵活性与性别无关。我们的数据提供了新的证据，表明性别在中枢给予血管紧张素II的生理特性中起决定性作用。
