Department of Geriatrics, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
J Am Geriatr Soc. 2012 Sep;60(9):1708-12. doi: 10.1111/j.1532-5415.2012.04142.x.
To investigate the relationship between frailty and incident vascular dementia (VaD).
Seven-year longitudinal study.
Three-City Study, a French prospective study designed to evaluate the risk of dementia and cognitive decline attributable to vascular risk factors.
Five thousand four hundred eighty community-dwelling persons aged 65 to 95.
An expert committee established a clinical diagnosis of VaD. Frailty was defined as having at least three of the following criteria: weight loss, weakness, exhaustion, slowness, and low physical activity. Participants with prior stroke or prevalent dementia at baseline were excluded from analyses. Multivariate models were used to evaluate the relationship between frailty and incident VaD.
At baseline, 6.5% of participants were classified as frail. After 7 years of follow-up, 54 persons were diagnosed with VaD, seven of whom where frail. In the proportional hazards models, frailty was marginally associated with greater risk of all types of dementia and was not associated with incident Alzheimer's disease, but frailty status was independently associated with incident VaD.
Frailty is a major risk factor for incident VaD, so its identification could contribute to better estimates of the risk of VaD in elderly adults.
探讨虚弱与血管性痴呆（VaD）发病之间的关系。
7 年纵向研究。
三城研究，一项旨在评估血管危险因素导致痴呆和认知能力下降风险的法国前瞻性研究。
5480 名年龄在 65 至 95 岁之间的社区居民。
一个专家委员会建立了 VaD 的临床诊断。虚弱被定义为至少有以下三个标准：体重减轻、虚弱、疲惫、缓慢和低身体活动。基线时有既往卒中或现患痴呆的参与者被排除在分析之外。多变量模型用于评估虚弱与新发 VaD 之间的关系。
在基线时，6.5%的参与者被归类为虚弱。在 7 年的随访后，54 人被诊断为 VaD，其中 7 人是虚弱的。在比例风险模型中，虚弱与所有类型痴呆的风险增加呈边缘相关，与阿尔茨海默病无关，但虚弱状态与新发 VaD 独立相关。
虚弱是新发 VaD 的一个主要危险因素，因此其识别可以有助于更好地估计老年人患 VaD 的风险。
