Smart Philip, Burbury Kate, Lingaratnam Senthil, Lynch A Craig, Mackay John, Heriot Alexander
Department of Cancer Surgery, Peter MacCallum Cancer Centre and Epworth Healthcare, Melbourne, Victoria, Australia.
ANZ J Surg. 2013 Sep;83(9):646-50. doi: 10.1111/j.1445-2197.2012.06245.x. Epub 2012 Sep 17.
Thromboembolism is a common cause of morbidity and mortality in patients with colorectal cancer, but thromboprophylaxis (TP) is underutilized. Current guidelines do not make specific recommendations for colorectal cancer patients and provide minimal guidance for the ambulatory setting, although emerging evidence suggests TP may be warranted during chemoradiotherapy or in the extended post-operative phase. A survey of Australasian colorectal surgeons was therefore performed to assess current TP practice and attitudes.
An online survey was sent to 204 surgeons who were members of the Colorectal Surgical Society of Australia and New Zealand.
One hundred twenty-eight surgeons (63%) completed the survey. Most surgeons consult available guidelines, and where recommendations are made, current practice is in line with them. Lack of data, lack of ownership, logistical issues and an absence of guideline recommendations currently prevent surgeons from instituting TP in the neoadjuvant treatment period. Fifty-four per cent of surgeons currently prescribe TP after hospital discharge; those that do not, cite logistical issues as the main constraint.
More data on thromboembolism risk during various treatment phases are required and should be promulgated in tumour-specific guidelines. Logistical barriers to adopting TP in the ambulatory setting should be addressed.
血栓栓塞是结直肠癌患者发病和死亡的常见原因,但血栓预防(TP)措施未得到充分利用。目前的指南未针对结直肠癌患者给出具体建议,且对门诊环境的指导极少,尽管新出现的证据表明在放化疗期间或术后延长阶段可能需要进行血栓预防。因此,对澳大利亚和新西兰的结直肠外科医生进行了一项调查,以评估当前的血栓预防实践和态度。
向204名澳大利亚和新西兰结直肠外科学会成员的外科医生发送了在线调查问卷。
128名外科医生(63%)完成了调查。大多数外科医生会参考现有指南,且在有推荐的情况下,当前的实践与指南一致。缺乏数据、缺乏自主权、后勤问题以及缺乏指南推荐目前阻碍了外科医生在新辅助治疗期间实施血栓预防。目前,54%的外科医生在患者出院后开具血栓预防药物;未这样做的医生将后勤问题视为主要制约因素。
需要更多关于不同治疗阶段血栓栓塞风险的数据,并应在特定肿瘤指南中公布。应解决在门诊环境中采用血栓预防措施的后勤障碍。