Institute of Clinical Pharmacology, Goethe-University, D-60590 Frankfurt am Main, Germany.
Int J Psychophysiol. 2012 Nov;86(2):182-6. doi: 10.1016/j.ijpsycho.2012.09.003. Epub 2012 Sep 15.
Self-reports of fibromyalgia (FM) patients about an enhanced olfactory acuity have been used to characterize them as persons with a general increased sensitivity to sensory input consistent with a central sensitization. However, as reduced activations in some brain areas also seem to accompany FM, a multisensory hypersensitivity is not a necessary consequence.
FM patients meeting ARA (American Rheumatism Association) criteria (16 women and one man, aged 23-56 years, spontaneous pain 32-91 mm visual analog scale [VAS], 14-18 tender points with a pressure pain threshold of 1.5±0.7 kg/cm(2)) received an olfactory test (Sniffn' Sticks) to assess their odor thresholds to n-butanol and their ability to discriminate and identify odors. Healthy controls were 14 age-matched women and one man.
Patients had poorer odor identification than controls (14.6±1.3 vs. 15.5±0.6; p<0.05) but did not differ in odor thresholds or odor discrimination. This test result contrasted with the patients' self-ratings of their olfactory sensitivity as higher than average.
The perception of FM patients as being multisensory hypersensitive is not supported by present results. In contrast to the subjects' self-ratings, measurements of olfactory function showed a slightly reduced odor identification, with a by-and-large normal performance.
纤维肌痛（FM）患者自我报告的嗅觉敏锐度增强，这一特征使他们被认为是对感官输入普遍敏感的人，与中枢敏化一致。然而，由于一些大脑区域的活动减少似乎也伴随着 FM，因此多感官过敏并不是必然的结果。
符合 ARA（美国风湿病协会）标准的 FM 患者（16 名女性和 1 名男性，年龄 23-56 岁，自发疼痛 32-91 毫米视觉模拟量表[VAS]，14-18 个压痛点，压力疼痛阈值为 1.5±0.7 kg/cm²）接受嗅觉测试（Sniffn' Sticks），以评估他们对正丁醇的嗅觉阈值以及区分和识别气味的能力。健康对照组由 14 名年龄匹配的女性和 1 名男性组成。
患者的嗅觉识别能力比对照组差（14.6±1.3 对 15.5±0.6；p<0.05），但嗅觉阈值或嗅觉辨别力无差异。这一测试结果与患者自我报告的嗅觉敏感性高于平均水平相矛盾。
目前的结果不支持 FM 患者多感官过敏的观点。与患者的自我评估相反，嗅觉功能测量显示嗅觉识别略有下降，但总体表现正常。
