Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Semin Radiat Oncol. 2012 Oct;22(4):284-94. doi: 10.1016/j.semradonc.2012.05.005.
The majority of men diagnosed with prostate cancer are diagnosed later in life. Although localized prostate cancer is often an indolent disease, older men are more frequently diagnosed with high-risk disease and are more likely to die from prostate cancer than younger men. Comorbid medical conditions are also more prevalent in the later decades of life and can impact prostate cancer treatment tolerance and the likelihood of benefiting from aggressive cancer treatment. Older men diagnosed with prostate cancer are at risk for both overtreatment of low-risk disease and undertreatment of high-risk disease. Prostate cancer management decisions for older patients should be tailored based on an individual patient's health status, coexisting medical conditions, life expectancy, and tumor characteristics.
大多数被诊断患有前列腺癌的男性都是在晚年被诊断出来的。虽然局限性前列腺癌通常是一种惰性疾病，但老年男性更常被诊断为高危疾病，并且比年轻男性更容易死于前列腺癌。同时，在生命的后期几十年中，合并症也更为普遍，这可能会影响前列腺癌治疗的耐受性以及从积极治疗中获益的可能性。被诊断患有前列腺癌的老年男性既有过度治疗低危疾病的风险，也有治疗高危疾病不足的风险。对于老年患者，应根据患者的健康状况、合并症、预期寿命和肿瘤特征，对前列腺癌的管理决策进行个体化定制。
