糖尿病大鼠颌下腺 GLP-1 的表达。

GLP-1 expression in von Ebner's gland of diabetic rats.

机构信息

Department of Endocrinology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, China.

出版信息

Peptides. 2012 Nov;38(1):137-41. doi: 10.1016/j.peptides.2012.09.002. Epub 2012 Sep 7.

DOI:10.1016/j.peptides.2012.09.002

PMID:22986021

Abstract

GLP-1, a peptidergic endocrine hormone, which associate with appetite control, glucose homeostasis and satiety. It might play an important role in the gustatory system. We tried to investigate the expression of GLP-1 in von Ebner's gland of diabetic and control rats, and the ultrastructure changes on von Ebner's gland of diabetes rats. GLP-1 expression in von Ebner's gland was evaluated by immunohistochemistry. The number of GLP-1 positive cells in diabetic rat von Ebner's gland was significantly higher than that in normal controls. Electron micrographs showed that a series of pathologic changes in von Ebner's gland of diabetes rats. The results suggest that GLP-1 have some effects within the gustatory systems, and elevated von Ebner's gland GLP-1 expression may be one cause of diabetic taste impairment.

摘要

GLP-1 是一种肽类内分泌激素，与食欲控制、葡萄糖稳态和饱腹感有关。它可能在味觉系统中发挥重要作用。我们试图研究 GLP-1 在糖尿病和对照大鼠 von Ebner 腺中的表达，以及糖尿病大鼠 von Ebner 腺的超微结构变化。通过免疫组织化学评估 von Ebner 腺中 GLP-1 的表达。糖尿病大鼠 von Ebner 腺中 GLP-1 阳性细胞的数量明显高于正常对照组。电镜照片显示，糖尿病大鼠 von Ebner 腺发生了一系列病理变化。结果表明，GLP-1 在味觉系统中具有一定的作用，而升高的 von Ebner 腺 GLP-1 表达可能是糖尿病味觉障碍的原因之一。