DQ多态性：DQw4α和β膜近端区域分析
DQ polymorphism: an analysis of DQw4 alpha and beta membrane proximal regions.
作者信息
Hurley C K, Steiner N
机构信息
Department of Microbiology, Georgetown University, Washington, D.C.
出版信息
Hum Immunol. 1990 Feb;27(2):100-10. doi: 10.1016/0198-8859(90)90107-z.
The complete coding sequences of cDNA clones encoding the DQw4 alpha and beta polypeptides have been determined from two individuals expressing the DRw18(3), DQw4 haplotype. Although the first domain nucleotide sequence of the DQ alpha cDNA is very similar to the DQw2 alpha sequence, the sequence of the membrane proximal region (encoding second domain, transmembrane, and cytoplasmic segments) is more similar to DQw3-like alpha-gene sequences. The nucleotide sequence of the membrane proximal region of the DQw4 beta gene is identical to the DQw8 sequence in contrast to the extensive differences in the region encoding the first domains of these polypeptides. These sequences have been used to determine the evolutionary relationships among DQ alpha and beta genes.
已从两名表达DRw18(3)、DQw4单倍型的个体中确定了编码DQw4α和β多肽的cDNA克隆的完整编码序列。虽然DQα cDNA的第一个结构域核苷酸序列与DQw2α序列非常相似，但膜近端区域（编码第二个结构域、跨膜和细胞质区段）的序列与DQw3样α基因序列更相似。与这些多肽第一个结构域编码区域的广泛差异形成对比的是，DQw4β基因膜近端区域的核苷酸序列与DQw8序列相同。这些序列已被用于确定DQα和β基因之间的进化关系。
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