Department of Obstetrics and Gynecology, King Khalid University Hospital, Riyadh, Saudi Arabia.
Int J Gynaecol Obstet. 2012 Dec;119(3):224-6. doi: 10.1016/j.ijgo.2012.07.008. Epub 2012 Sep 15.
To identify morbidity and pregnancy outcomes associated with sickle cell disease (SCD) among pregnant Saudi women.
A 10-year retrospective study was conducted at King Khalid University Hospital in Riyadh, Saudi Arabia, that included 392 cases of SCD in pregnancy and 784 controls with normal hemoglobin phenotype, who were selected and matched for age, parity, and delivery outcome. The main outcome measures were morbidity, maternal outcomes, and fetal outcomes.
The incidence of SCD was 1.1% among all deliveries, with 2 maternal deaths (0.5%) and a perinatal mortality rate of 77.7 per 1000 deliveries. The major maternal complications in the SCD group were anemia (86.2%); sickle cell crisis (64.8% overall, with 43.1% vaso-occlusive, 21.2% hemolytic, and 0.5% sequestration or aplastic); bacterial infection (8.8%); preterm delivery (15.3%); and pre-eclampsia (9.7%). Fetal growth restriction and stillbirths accounted for 65.6% of the perinatal mortality. Blood transfusion was indicated in 33.7% of pregnancies in the SCD group.
Pregnant Saudi women with SCD are at increased risk for pregnancy-related complications, as well as fetal morbidity and mortality. A critical need exists among Saudi hospitals for a multidisciplinary approach to the management of pregnancies complicated by SCD.
鉴定与沙特妊娠女性镰状细胞病（SCD）相关的发病率和妊娠结局。
这是一项在沙特阿拉伯利雅得的 King Khalid 大学医院进行的为期 10 年的回顾性研究，共纳入 392 例妊娠合并 SCD 患者和 784 例血红蛋白表型正常的对照患者，对这些患者进行了年龄、产次和分娩结局的匹配选择。主要结局指标为发病率、母体结局和胎儿结局。
SCD 在所有分娩中的发病率为 1.1%，有 2 例产妇死亡（0.5%），围产期死亡率为每 1000 例分娩 77.7 例。SCD 组的主要母体并发症包括贫血（86.2%）；镰状细胞危象（总体发生率为 64.8%，其中血管阻塞性危象占 43.1%、溶血性危象占 21.2%、脾脏扣押或再生障碍性危象占 0.5%）；细菌感染（8.8%）；早产（15.3%）；子痫前期（9.7%）。胎儿生长受限和死胎占围产期死亡率的 65.6%。SCD 组中 33.7%的妊娠需要输血。
沙特妊娠女性患有 SCD 时，妊娠相关并发症以及胎儿发病率和死亡率的风险增加。沙特医院需要一种多学科方法来管理由 SCD 引起的妊娠。
