Morel N, Berthoux E, Colombe B, Bosseray A, Massot C
Clinique de médecine interne, hôpital Michallon, CHU de Grenoble, BP 217, 38043 Grenoble cedex 09, France.
Rev Med Interne. 2012 Nov;33(11):640-2. doi: 10.1016/j.revmed.2012.08.012. Epub 2012 Sep 15.
Q fever can commonly mimic systemic diseases, leading to several immunological manifestations. Thrombotic micro-angiopathies manifest as a spectrum of related disorders in the form of thrombocytopenic purpura and hemolytic uremic syndrome.
We report a 77-year-old woman, who presented an acquired thrombotic microangiopathy with renal expression associated with the presence of anti-ADAMTS 13 antibodies, which occurred during an acute infection by Coxiella burnetii (acute Q fever).
Auto-immune disorders are well-known in chronic or acute Q fever but to our knowledge, this is the first reported observation of thrombotic microangiopathy with anti-ADAMTS 13 antibodies.
Q热通常可模仿全身性疾病，导致多种免疫表现。血栓性微血管病表现为一系列相关疾病，形式为血小板减少性紫癜和溶血尿毒综合征。
我们报告一名77岁女性，其出现了伴有肾脏表现的获得性血栓性微血管病，与抗ADAMTS 13抗体的存在相关，该情况发生在伯纳特柯克斯体急性感染（急性Q热）期间。
自身免疫性疾病在慢性或急性Q热中很常见，但据我们所知，这是首次报道的伴有抗ADAMTS 13抗体的血栓性微血管病观察病例。
Zotero 插件