Department of Internal Medicine, University Hospital Basel, Basel, Switzerland.
Nephrol Dial Transplant. 2010 May;25(5):1720-2. doi: 10.1093/ndt/gfq021. Epub 2010 Jan 28.
In this case report, we describe for the first time a patient with thrombotic thrombocytopaenic purpura (TTP) accompanying highly active systemic lupus erythematosus (SLE) that was associated with non-neutralizing antibodies against the plasma metalloprotease ADAMTS13. Those non-neutralizing antibodies could have been the cause of ADAMTS13 depletion and consecutive TTP. More extensive analyses are required to determine the prevalence as well as the clinical relevance of non-neutralizing antibodies against ADAMTS13 in SLE patients.
在本病例报告中，我们首次描述了一例伴有高度活跃系统性红斑狼疮（SLE）的血栓性血小板减少性紫癜（TTP）患者，该患者与针对血浆金属蛋白酶 ADAMTS13 的非中和抗体有关。这些非中和抗体可能是 ADAMTS13 耗竭和随后发生 TTP 的原因。需要更广泛的分析来确定 SLE 患者中针对 ADAMTS13 的非中和抗体的流行率及其临床相关性。
