局部用普瑞巴林和双氯芬酸治疗大鼠神经性口面痛。
Topical pregabalin and diclofenac for the treatment of neuropathic orofacial pain in rats.
机构信息
Center for Temporomandibular Disorders and Orofacial Pain, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, USA.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Oct;114(4):449-56. doi: 10.1016/j.oooo.2012.05.002.
OBJECTIVE
The aim of this study was to evaluate the effect of topical treatment with pregabalin and diclofenac on neuropathic orofacial pain induced by infraorbital nerve injury in the rat.
STUDY DESIGN
Sixty-four Sprague-Dawley rats underwent infraorbital nerve injury. Seven days after surgery, pain was verified and the rats randomly assigned to topical or systemic treatment with pregabalin or diclofenac, or to no treatment. Pain intensity and motor coordination were assessed at baseline, after surgery, and daily after treatment for 4 consecutive days. Medication plasma levels were assessed at the end of the study.
RESULTS
Topical treatment with 10% pregabalin or 5% diclofenac reduced the pain significantly. A significant decrease in motor coordination was found in the systemic pregabalin. The medications' plasma levels were significantly higher in the systemic treatment compared with the topical.
CONCLUSIONS
Topical treatment with pregabalin or diclofenac can reduce neuropathic orofacial pain induced by nerve injury.
目的
本研究旨在评估眶下神经损伤诱导的啮齿动物神经性口面疼痛的局部用普瑞巴林和双氯芬酸治疗效果。
研究设计
64 只 Sprague-Dawley 大鼠接受眶下神经损伤。手术后 7 天，验证疼痛并将大鼠随机分配至局部或全身用普瑞巴林或双氯芬酸治疗，或不治疗。在基线、手术后以及连续 4 天每天治疗后评估疼痛强度和运动协调。在研究结束时评估药物血浆水平。
结果
10%普瑞巴林或 5%双氯芬酸的局部治疗显著减轻了疼痛。全身用普瑞巴林显著降低了运动协调。与局部治疗相比，全身治疗的药物血浆水平显著更高。
结论
局部用普瑞巴林或双氯芬酸可减轻神经损伤诱导的神经性口面疼痛。
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