阿萨希毛霉对 20(S)-原人参三醇的微生物转化及其对两种人前列腺癌细胞系的细胞毒性。
Microbial transformation of 20(S)-protopanaxatriol by Absidia corymbifera and their cytotoxic activities against two human prostate cancer cell lines.
机构信息
School of Medicine, Nantong University, Nantong, People's Republic of China.
出版信息
Biotechnol Lett. 2013 Jan;35(1):91-5. doi: 10.1007/s10529-012-1053-x. Epub 2012 Sep 18.
Seven hydroxylates of 20(S)-protopanaxatriol (1) transformed by Absidia corymbifera AS 3.3387 were isolated and identified by spectral methods including 2D-NMR. Among them, 7β-hydroxyl-20(S)-protopanaxatriol (2), 7α-hydroxyl-20(S)-protopanaxatriol (3), and 7β, 15α-dihydroxyl-20(S)-protopanaxatriol (7) are new compounds. The metabolites 2, 6, 7, and 8 showed the more potent inhibitory effects against DU-145 and PC-3 cell lines than the substrate.
被 Absidia corymbifera AS 3.3387 转化的 20(S)-原人参三醇的七个羟基化物（1）通过光谱方法（包括 2D-NMR）被分离和鉴定。其中，7β-羟基-20(S)-原人参三醇（2）、7α-羟基-20(S)-原人参三醇（3）和 7β,15α-二羟基-20(S)-原人参三醇（7）是新化合物。代谢产物 2、6、7 和 8 对 DU-145 和 PC-3 细胞系的抑制作用强于底物。
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