Department of Internal Medicine, College of Medicine, Chung-Ang University, Dongjak-gu, Seoul, Republic of Korea.
Curr Hypertens Rep. 2012 Dec;14(6):510-6. doi: 10.1007/s11906-012-0309-0.
To further understand chronic heart disease, such as heart failure and cardiomyopathy, we must fully define signaling pathways within the myocardium. Recent studies suggest that some forms of heart disease are associated with a chronic low-grade inflammation that promotes adverse ventricular remodeling and correlates with disease progression. Several inflammatory mediators, including TNF-α, IL-1β, and IL-6, are involved in cardiac injury subsequent to myocardial ischemia and reperfusion, sepsis, viral myocarditis, and transplant rejection. Once activated, components of the inflammatory response can have both beneficial and deleterious effects on the heart. In this review, we discuss the complex inflammatory signaling pathways in the myocardium and potential therapeutic implications.
为了更深入地了解慢性心脏病，如心力衰竭和心肌病，我们必须充分定义心肌中的信号通路。最近的研究表明，某些形式的心脏病与慢性低度炎症有关，这种炎症会促进不良的心室重构，并与疾病进展相关。几种炎症介质，包括 TNF-α、IL-1β 和 IL-6，参与了心肌缺血再灌注、脓毒症、病毒性心肌炎和移植排斥后的心肌损伤。一旦被激活，炎症反应的成分对心脏既有有益的影响，也有有害的影响。在这篇综述中，我们讨论了心肌中复杂的炎症信号通路及其潜在的治疗意义。
