第一口综合征：3 例接受肉毒毒素治疗的病例报告及其他治疗方式的综述。
First bite syndrome: case report of 3 patients treated with botulinum toxin and review of other treatment modalities.
机构信息
University of Arkansas for Medical Sciences, Department of Otolaryngology - Head & Neck Surgery, Little Rock, Arkansas 72205, USA.
出版信息
Head Neck. 2013 Sep;35(9):E288-91. doi: 10.1002/hed.23150. Epub 2012 Sep 18.
BACKGROUND
First bite syndrome is an unexpected yet relatively common complication of surgeries involving the parapharyngeal space. It can have a significant effect on both the quality of life and physical health of affected patients. This study presents 3 cases of first bite syndrome treated with botulinum toxin and a review of the current literature on available treatment modalities for first bite syndrome.
METHODS
Three patients with first bite syndrome were injected with 75 units of botulinum toxin into affected parotid glands, focusing on areas of greatest first bite pain.
RESULTS
Two of 3 patients experienced complete relief of symptoms for 4 to 6 months. The third patient had significant decrease in pain at 4-month follow-up.
CONCLUSIONS
Many treatments for first bite syndrome have been attempted including: dietary modification, pharmacological treatments, and surgical treatments. However, few have been successful. Botulinum toxin is a safe and effective treatment for this life altering and difficult to treat first bite syndrome.
背景
第一口综合征是涉及咽旁间隙手术的一种意外但相对常见的并发症。它会对受影响患者的生活质量和身体健康产生重大影响。本研究介绍了 3 例采用肉毒毒素治疗的第一口综合征病例，并回顾了目前关于第一口综合征治疗方法的文献。
方法
3 例第一口综合征患者在受影响的腮腺中注射了 75 单位的肉毒毒素，重点关注第一口疼痛最严重的区域。
结果
3 例中有 2 例患者的症状完全缓解，持续 4 至 6 个月。第 3 例患者在 4 个月随访时疼痛明显减轻。
结论
已经尝试了许多治疗第一口综合征的方法，包括：饮食调整、药物治疗和手术治疗。然而，很少有成功的。肉毒毒素是一种安全有效的治疗方法，可用于治疗这种改变生活和难以治疗的第一口综合征。
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