p53 家族逐渐衰老。
The p53 family grows old.
机构信息
Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
出版信息
Genes Dev. 2012 Sep 15;26(18):1997-2000. doi: 10.1101/gad.202648.112.
Abstract
p73 and p63 are evolving members of the p53 tumor suppressor family. TAp73 is a p73 isoform with a potent transcriptional activation domain, and loss of TAp73 predisposes mice to tumor development. In this issue of Genes & Development, Rufini and colleagues (pp. 2009-2014) discuss how TAp73-null mice display an aging phenotype that is due to mitochondrial dysfunction. Specifically, decreased levels of cytochrome C oxidase subunit 4 isoform 1 (Cox4i1) impair cytochrome C oxidase (COX) function, the multimeric enzyme that executes the last step in aerobic respiration. An emerging theme is that defects in metabolism account for both cancer and aging.
摘要
p73 和 p63 是 p53 肿瘤抑制因子家族的进化成员。TAp73 是一种具有强大转录激活结构域的 p73 同工型，TAp73 的缺失会使小鼠易患肿瘤。在本期《基因与发育》中，Rufini 及其同事（第 2009-2014 页）讨论了 TAp73 缺失小鼠如何表现出衰老表型，这是由于线粒体功能障碍。具体来说，细胞色素 C 氧化酶亚基 4 同工型 1（Cox4i1）水平降低会损害细胞色素 C 氧化酶（COX）的功能，COX 是执行需氧呼吸最后一步的多聚酶。一个新出现的主题是，代谢缺陷既是癌症又是衰老的原因。
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本文引用的文献
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2
Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence.在没有 p53 介导的细胞周期阻滞、细胞凋亡和衰老的情况下抑制肿瘤。
Cell. 2012 Jun 8;149(6):1269-83. doi: 10.1016/j.cell.2012.04.026.
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Nature. 2011 Feb 17;470(7334):359-65. doi: 10.1038/nature09787. Epub 2011 Feb 9.
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TAp73 acts via the bHLH Hey2 to promote long-term maintenance of neural precursors.TAp73 通过 bHLH Hey2 发挥作用，促进神经前体细胞的长期维持。
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