Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Genes Dev. 2012 Sep 15;26(18):1997-2000. doi: 10.1101/gad.202648.112.
p73 and p63 are evolving members of the p53 tumor suppressor family. TAp73 is a p73 isoform with a potent transcriptional activation domain, and loss of TAp73 predisposes mice to tumor development. In this issue of Genes & Development, Rufini and colleagues (pp. 2009-2014) discuss how TAp73-null mice display an aging phenotype that is due to mitochondrial dysfunction. Specifically, decreased levels of cytochrome C oxidase subunit 4 isoform 1 (Cox4i1) impair cytochrome C oxidase (COX) function, the multimeric enzyme that executes the last step in aerobic respiration. An emerging theme is that defects in metabolism account for both cancer and aging.
p73 和 p63 是 p53 肿瘤抑制因子家族的进化成员。TAp73 是一种具有强大转录激活结构域的 p73 同工型，TAp73 的缺失会使小鼠易患肿瘤。在本期《基因与发育》中，Rufini 及其同事（第 2009-2014 页）讨论了 TAp73 缺失小鼠如何表现出衰老表型，这是由于线粒体功能障碍。具体来说，细胞色素 C 氧化酶亚基 4 同工型 1（Cox4i1）水平降低会损害细胞色素 C 氧化酶（COX）的功能，COX 是执行需氧呼吸最后一步的多聚酶。一个新出现的主题是，代谢缺陷既是癌症又是衰老的原因。
