低分子量肝素预防亚洲普通外科患者深静脉血栓形成：克什米尔地区的经验。
Low molecular weight heparin in prophylaxis of deep vein thrombosis in Asian general surgical patients: A Kashmir experience.
作者信息
Dar Tanveer Iqbal, Wani Khursheed Alam, Ashraf Mohd, Malik Aijaz, Ahmad Sanjeed, Gojwari Tariq A, Iqbal Arshad
机构信息
Department of General Surgery, SKIMS Soura, and SKIMS Medical College, Srinagar, J and K, India.
出版信息
Indian J Crit Care Med. 2012 Apr;16(2):71-4. doi: 10.4103/0972-5229.99107.
BACKGROUND AND OBJECTIVES
Deep vein thrombosis (DVT) occurs at a lower rate in Asia than in the rest of the world. We wanted to study the significance and efficacy of low molecular weight heparin (LMWH) in prophylaxis of DVT in major general surgical patients in the Kashmir Valley (India, Asia) so as to make it a routine in our patients.
PATIENTS AND METHODS
This was a prospective study in which the effect of LMWH was compared with no prophylaxis.
RESULTS
LMWHs are more effective than no prophylaxis in the prevention of DVT and pulmonary thromboembolism in highest-risk general surgical patients (odds ratio = 16.64; 95% confidence interval = 3.63-1130.03; P-value = 0.014).
CONCLUSION
LMWHs have a significant prophylactic effect on DVT in general surgical patients, with a higher benefit to risk ratio, and, in spite of the low incidence of DVT in Asia, its prophylaxis should routinely be considered in this part of the world as well, preferably in the form of LMWHs.
背景与目的
亚洲深静脉血栓形成（DVT）的发生率低于世界其他地区。我们旨在研究低分子量肝素（LMWH）对克什米尔山谷（印度，亚洲）普通外科主要患者预防DVT的意义和疗效，以便将其作为我们患者的常规预防措施。
患者与方法
这是一项前瞻性研究，将LMWH的效果与不进行预防进行比较。
结果
在高危普通外科患者中，LMWH预防DVT和肺血栓栓塞比不进行预防更有效（优势比=16.64；95%置信区间=3.63-1130.03；P值=0.014）。
结论
LMWH对普通外科患者的DVT有显著预防作用，效益风险比更高，尽管亚洲DVT发病率较低，但在世界这一地区也应常规考虑对其进行预防，最好采用LMWH的形式。
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