Nellessen E, Piérard L
Service de cardiologie, CHU Sart-Tilman 4000 Liège, Belgique.
Rev Med Suisse. 2012 Aug 29;8(351):1591-7.
Heart failure constitutes a major public health problem. Its incidence continues to grow and its prognosis remains poor. Therapeutic approach of chronic heart failure with left ventricular systolic dysfunction is well codified. Recommended medical treatment is presented with the description of the different therapeutic classes. Recent advances are discussed. New therapeutic targets are described. Optimization of recognized treatment and application to heart failure of drugs used for other indications are developed. Therapeutic approach of heart failure with preserved ejection fraction is tackled but stays far less well defined. Many studies concerning treatment of acute heart failure are ongoing.
心力衰竭是一个重大的公共卫生问题。其发病率持续上升,预后仍然很差。慢性左心室收缩功能不全性心力衰竭的治疗方法已得到很好的规范。推荐的药物治疗方案与不同治疗类别的描述一同呈现。文中讨论了近期的进展。描述了新的治疗靶点。对已认可治疗方法的优化以及用于其他适应症的药物在心力衰竭中的应用也有所阐述。射血分数保留的心力衰竭的治疗方法也有涉及,但仍远未明确。许多关于急性心力衰竭治疗的研究正在进行中。