Lian Derrick W Q, Lam Joyce C M, Aung Aye Chan Lwin, Li Faye X, Chang Kenneth T E
Department of Pathology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433.
Pediatr Dev Pathol. 2013 Jan-Feb;16(1):28-31. doi: 10.2350/12-08-1242-CR.1. Epub 2012 Sep 18.
Fetal thrombotic vasculopathy (FTV) is a thrombo-occlusive disorder of the placenta that has been reported in association with perinatal conditions such as cardiac abnormalities, neurological injury, and perinatal liver disease. These complications are related to fetal circulation vascular compromise. We herein report a previously undocumented association of congenital intestinal atresia and placental FTV. Vascular occlusion of the fetal mesenteric vessels has been hypothesized to result in congenital intestinal atresia. Our report provides support for this vascular hypothesis and illustrates the value of formal pathological examination of the placenta in explaining this occurrence of congenital intestinal atresia.
胎儿血栓性血管病（FTV）是一种胎盘的血栓闭塞性疾病，已有报道称其与围产期疾病相关，如心脏异常、神经损伤和围产期肝病。这些并发症与胎儿循环血管受损有关。我们在此报告先天性肠闭锁与胎盘FTV之间一种此前未被记录的关联。据推测，胎儿肠系膜血管的血管闭塞会导致先天性肠闭锁。我们的报告为这一血管假说提供了支持，并说明了胎盘的正式病理检查在解释先天性肠闭锁发生情况方面的价值。
