Zhang Yong, Li Jin-Xia
Department of Pediatrics, Maternity and Children's Health Hospital, Dongguan, Guangdong, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2012 Sep;14(9):675-7.
To investigate current infection with Helicobacter pylori (H. pylori) and related risk factors in children with gastrointestinal symptoms.
A total of 376 children with upper gastrointestinal symptoms were examined by gastroscopy. Three pieces of gastric mucosa were sampled for rapid urease test and pathohistological examination. Some children received 13C-urea breath test. Children with two or more positive results were diagnosed with H. pylori infection. A questionnaire on living environment, family economic status, parents' education level and family history of gastrointestinal diseases was completed for all children.
The H. pylori infection rate was 44.9% (169/376) in children with upper gastrointestinal symptoms. There was no statistical difference in the infection rate between males and females (P>0.05). The H. pylori infection rates in the 3 to 7-year old, 8 to 12-year old and 13 to 16-year-old children were 39.5% (47/119), 41.0% (55/134), and 54.5% (67/123) respectively, with significant differences between different age groups (χ2=6.76, P<0.05). The H. pylori positive rate was significantly higher in children who were in full-time nursery or collective living and dining than in those who were not (53.6% vs 40.6%; P<0.05). The H. pylori positive rate in high-income families was lower than that in middle to low-income families (36.9% vs 48.3%; P<0.05). In addition, the H. pylori positive rate in children with well-educated parents was lower than in those with parents who had not received higher education (39.5% vs 50.8%; P<0.05). The H. pylori infection rate in children with a family history of digestive disease was significantly higher than in those without family history of gastrointestinal diseases (52.9% vs 41.2%; P<0.05).
The infection rate increases with age and is higher in children who are in collective living and dining, come from low income family, have parents who have not received higher education and have a family history of upper gastrointestinal diseases.
调查有胃肠道症状儿童的幽门螺杆菌（H. pylori）现感染情况及相关危险因素。
对376例有上消化道症状的儿童进行胃镜检查。取3块胃黏膜组织进行快速尿素酶试验和病理组织学检查。部分儿童接受13C尿素呼气试验。两项或以上检查结果为阳性的儿童被诊断为幽门螺杆菌感染。为所有儿童完成一份关于生活环境、家庭经济状况、父母教育水平和胃肠道疾病家族史的问卷。
有上消化道症状儿童的幽门螺杆菌感染率为44.9%（169/376）。男女感染率差异无统计学意义（P>0.05）。3至7岁、8至12岁和13至16岁儿童的幽门螺杆菌感染率分别为39.5%（47/119）、41.0%（55/134）和54.5%（67/123），不同年龄组间差异有统计学意义（χ2=6.76，P<0.05）。全日制托儿所或集体生活就餐儿童的幽门螺杆菌阳性率显著高于非此类儿童（53.6%对40.6%；P<0.05）。高收入家庭儿童的幽门螺杆菌阳性率低于中低收入家庭（36.9%对48.3%；P<0.05）。此外，父母受过良好教育的儿童幽门螺杆菌阳性率低于父母未接受高等教育的儿童（39.5%对50.8%；P<0.05）。有消化系统疾病家族史儿童的幽门螺杆菌感染率显著高于无胃肠道疾病家族史儿童（52.9%对41.2%；P<0.05）。
感染率随年龄增长而升高，在集体生活就餐、来自低收入家庭、父母未接受高等教育且有上消化道疾病家族史的儿童中更高。
