细胞毒性T淋巴细胞相关抗原4 +49A/G多态性与儿童1型糖尿病的关联：一项荟萃分析

[Association of cytotoxic T lymphocyte-associated antigen-4+49A/G polymorphism with childhood type 1 diabetes mellitus: a meta-analysis].

作者信息

Luo Shu-Ying, Tan Li-Na, Wei Hai-Yan, Zhang Yao-Dong, Chen Yong-Xing

机构信息

Department of Endocrinology, Zhengzhou Children's Hospital, Zhengzhou, China.

出版信息

Zhongguo Dang Dai Er Ke Za Zhi. 2012 Sep;14(9):683-8.

PMID:22989439

Abstract

OBJECTIVE

To evaluate the association of cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) + 49A/G polymorphism with type 1 diabetes mellitus (T1DM) in children.

METHODS

Papers about the association of CTLA4+49A/G polymorphism with T1DM in children were collected by searching PubMed, EBSCO, CBM, CNKI, and Wanfang Data. A meta-analysis was performed to examine differences in the genotypes (AG, GG, and GG+AG) and G allele at position 49 of the CTLA-4 gene between a childhood T1DM group and a control group.

RESULTS

A total of 10 papers involving 1084 T1DM children and 1338 healthy children were included. The Meta-analysis was performed to evaluate the association of the genotypes (AG, GG, and GG+AG) and the G allele at position 49 of the CTLA-4 gene with T1DM using a fixed effect model according to the heterogeneity test results of all studies. The pooled OR values (95% CI) were 1.13 (0.97-1.33), 1.42 (1.16-1.75), 1.20 (1.03-1.40), and 1.21 (1.09-1.33), suggesting a significant difference in genotypes (AG, GG, and GG+AG) and the G allele at position 49 of the CTLA-4 gene between the two groups.

CONCLUSIONS

CTLA-4 +49A/G polymorphism is associated with T1DM in children.

摘要

目的

评估细胞毒性T淋巴细胞相关抗原4（CTLA-4）+49A/G多态性与儿童1型糖尿病（T1DM）的相关性。

方法

通过检索PubMed、EBSCO、CBM、CNKI和万方数据收集关于CTLA4+49A/G多态性与儿童T1DM相关性的文献。进行荟萃分析，以检验儿童T1DM组和对照组之间CTLA-4基因第49位的基因型（AG、GG和GG+AG）和G等位基因的差异。

结果

共纳入10篇文献，涉及1084例T1DM儿童和1338例健康儿童。根据所有研究的异质性检验结果，采用固定效应模型进行荟萃分析，以评估CTLA-4基因第49位的基因型（AG、GG和GG+AG）和G等位基因与T1DM的相关性。合并的OR值（95%CI）分别为1.13（0.97-1.33）、1.42（1.16-1.75）、1.20（1.03-1.40）和1.21（1.09-1.33），表明两组之间CTLA-4基因第49位的基因型（AG、GG和GG+AG）和G等位基因存在显著差异。