Lotz J C, Gerhart T N, Hayes W C
Department of Orthopaedic Surgery, Charles A. Dana Research Institute, Beth Israel Hospital, Boston, MA 02215.
J Comput Assist Tomogr. 1990 Jan-Feb;14(1):107-14. doi: 10.1097/00004728-199001000-00020.
We have investigated the relationships between trabecular bone compressive strength and elastic modulus and the directly measured apparent density and noninvasively measured CT equivalent mineral density for 49 cylindrical specimens harvested from fresh human proximal femora. Compressive strength demonstrated a high positive correlation with both densities, being proportional to the apparent density raised to the 1.8 power (R2 = 0.93) and equivalent mineral density to the 1.5 power (R2 = 0.89). Similarly, the compressive modulus demonstrated a high correlation with both density measures, being proportional to the apparent density raised to the 1.4 power (R2 = 0.91) and CT equivalent mineral density to the 1.2 power (R2 = 0.90). Though variations in architecture and bone marrow fat were observed to influence trabecular properties, the data presented here demonstrate that apparent density, compressive strength, and elastic modulus can be determined accurately using single energy quantitative CT. We expect that the use of these noninvasive data will result in improved estimates of that component of hip fracture risk that is attributable to bone strength.
我们研究了从新鲜人近端股骨获取的49个圆柱形标本的小梁骨抗压强度与弹性模量，以及直接测量的表观密度和非侵入性测量的CT等效矿物质密度之间的关系。抗压强度与两种密度均呈现高度正相关，与表观密度的1.8次方成正比（R2 = 0.93），与等效矿物质密度的1.5次方成正比（R2 = 0.89）。同样，压缩模量与两种密度测量值高度相关，与表观密度的1.4次方成正比（R2 = 0.91），与CT等效矿物质密度的1.2次方成正比（R2 = 0.90）。尽管观察到结构和骨髓脂肪的变化会影响小梁特性，但此处给出的数据表明，使用单能定量CT可以准确测定表观密度、抗压强度和弹性模量。我们预计，使用这些非侵入性数据将改善对归因于骨强度的髋部骨折风险成分的估计。
