Department of Animal Pathology, Faculty of Veterinary Medicine, University of Las Palmas de Gran Canaria, Spain.
Res Vet Sci. 2013 Apr;94(2):277-84. doi: 10.1016/j.rvsc.2012.08.003. Epub 2012 Sep 16.
The current study was conducted to isolate a field strain of Eimeria ninakohlyakimovae, characterize its infectivity and the response to challenge under experimental conditions. The isolated strain (GC) induced a prepatent period of 14-15 days p.i., a patency of 7±2 days and a noticeable pathogenicity in infected goat kids. Challenge trials resulting in a decrease of oocysts per gram counts as well as a milder intensity of clinical signs in re-infected animals indicated the capacity of this strain to induce protective immune response. Altogether, the data reported in the present study suggest that the strain E. ninakohlyakimovae GC is a useful tool for the investigation of mechanisms of pathogenicity as well as host protective immune response in caprine coccidiosis, representing a valuable prerequisite for the development of future strategies in prophylaxis and control of this important parasitic disease in goat.
本研究旨在分离一株纳氏艾美耳球虫田间分离株,对其在实验条件下的感染性和对攻毒的反应进行鉴定。分离株(GC)诱导感染山羊的潜伏期为 14-15 天,持续期为 7±2 天,具有明显的致病性。攻毒试验导致每克卵囊数减少,再感染动物的临床症状也较轻,表明该菌株能够诱导保护性免疫反应。总之,本研究报道的数据表明,E. ninakohlyakimovae GC 株是研究山羊球虫病致病性和宿主保护性免疫反应的有用工具,为未来制定预防和控制这种重要寄生虫病的策略提供了有价值的前提条件。