Vukusic S
Service de neurologie A et fondation Eugène Devic EDMUS pour la sclérose en plaques, hôpital neurologique Pierre-Wertheimer, hospices civils de Lyon, 59 boulevard Pinel, Lyon-Bron cedex, France.
Rev Neurol (Paris). 2012 Nov;168(11):836-45. doi: 10.1016/j.neurol.2012.07.008. Epub 2012 Sep 16.
Multiple sclerosis (MS) is the most frequent source of chronic neurological disability in Western countries, and its incidence and prevalence are increasing. However, it is possible to determine its prodromal phase and the radiological, biological and immunological endophenotypes that are present before the clinical onset of the disease, despite remaining unseen with the naked eye. In this context, greater knowledge of the aetiological factors, both genetic and environmental, may lead the way towards primary prevention strategies for MS in the near future.
多发性硬化症(MS)是西方国家慢性神经功能障碍最常见的病因,其发病率和患病率正在上升。然而,尽管在临床发病前肉眼无法察觉,但仍有可能确定其前驱期以及疾病临床发作前存在的放射学、生物学和免疫学内表型。在这种背景下,对遗传和环境等病因因素的更多了解可能会在不久的将来引领多发性硬化症一级预防策略的发展方向。