Okamoto Natsumi, Nambu Takuo, Matsuda Yuki, Matsuo Koji, Osaki Keisuke, Kanai Yugo, Ogawa Yoshihisa, Yonemitsu Shin, Kita Ryuichi, Muro Seiji, Sugawara Akira, Oki Shogo
Department of Diabetes Mellitus and Endocrinology, Osaka Red Cross Hospital, Japan.
Intern Med. 2012;51(18):2591-5. doi: 10.2169/internalmedicine.51.7981. Epub 2012 Sep 15.
Acid-base imbalances and electrolyte disorders induced by proton pump inhibitors (PPIs) are extremely rare. However, under certain conditions, PPIs may cause metabolic acidosis or hypokalemia, probably due to an inhibitory action on the proton pump that contributes to H(+) and K(+) homeostasis in the kidney. We herein present a case of marked hypokalemia accompanied by distal renal tubular acidosis in which a PPI appeared to contribute to the pathophysiology of metabolic acidosis.
质子泵抑制剂（PPIs）引起的酸碱失衡和电解质紊乱极为罕见。然而，在某些情况下，PPIs可能会导致代谢性酸中毒或低钾血症，这可能是由于其对质子泵的抑制作用，而质子泵有助于维持肾脏中H(+)和K(+)的稳态。我们在此报告一例伴有远端肾小管酸中毒的显著低钾血症病例，其中PPI似乎促成了代谢性酸中毒的病理生理过程。
