Division of Chemical Engineering, Hankyong National University, 167 Chungang-ro, Anseong-si, Gyeonggi-do 456-749, South Korea.
Int J Pharm. 2012 Dec 15;439(1-2):296-306. doi: 10.1016/j.ijpharm.2012.09.019. Epub 2012 Sep 16.
This study focused on fabrication and characterization of porous core/sheath structured composite nanofibers with a core of blended salicylic acid (SA) and poly(ethylene glycol) (PEG) and a sheath of poly(lactic acid) (PLA) using a dual-capillary electrospinning system. Results of water contact angle measurements, field-emission scanning electron microscopy, and transmission electron microscopy indicated that feed rates of the core and sheath strongly affect the stability of the core/sheath structure and porous density of the composite nanofibers obtained, significantly influencing their SA release characteristics. At a lower ratio of feed rates of the core and the sheath, better stable core/sheath structures of nanofibers with higher porous density on the surface were formed resulting in a sustained release of SA over 5 days. Non-porous fibers showed a lower amount of drug release because the drug was embedded inside the core layer of the non-porous sheath layer. SA release from porous core/sheath nanofibers was described based on a one-dimensional Fickian diffusion mechanism, indicating that drug diffusion is a predominant factor in drug release. A cytotoxicity test suggested that the porous core/sheath nanofibers are non-toxic and support cell attachment. Therefore, this fiber mat may find application in the design of wound-healing patches with long-term activity.
本研究采用双毛细管静电纺丝系统，制备并表征了具有混合水杨酸（SA）和聚乙二醇（PEG）芯和聚乳酸（PLA）鞘的多孔核/鞘结构复合纳米纤维。水接触角测量、场发射扫描电子显微镜和透射电子显微镜的结果表明，芯和鞘的进料速率强烈影响所获得的核/鞘结构复合纳米纤维的稳定性和多孔密度，显著影响它们的 SA 释放特性。在较低的芯和鞘的进料速率比下，形成具有更高表面多孔密度的更稳定的纳米纤维核/鞘结构，导致 SA 在 5 天内持续释放。无孔纤维的药物释放量较低，因为药物被嵌入无孔鞘层的芯层内。基于一维菲克扩散机制描述了多孔核/鞘纳米纤维中的 SA 释放，表明药物扩散是药物释放的主要因素。细胞毒性试验表明，多孔核/鞘纳米纤维无毒性且支持细胞附着。因此，这种纤维垫可能在具有长效活性的伤口愈合贴片的设计中得到应用。
