Mandache E, Penescu M N
Carol Davila Clinical Hospital for Nephrology, Bucharest, Romania.
Rom J Morphol Embryol. 2012;53(3):629-33.
It is currently considered that hump dense deposits developed during an acute poststreptococcal glomerulonephritis become finally dissolute by three hypothetical mechanisms: loosing their electron density, internalization and processing by podocytes and by incorporation in the glomerular basal lamina (GBM). Analyzing ultrastructurally the association of polymorphonuclear leukocytes and hump deposits, we emphasized features endorsing the hypothesis that the immune complexes of dense deposits are discharged in the circulation under the leukocytes activity. The active polymorphonuclear cells are melting the GBM in the area of contact by complement activation and by the NAPlr bound plasmin. The reversed flow of immune complexes from humps towards the blood circulation leaves fading, wrinkled shaped humps, before total dissolution.
目前认为，急性链球菌感染后肾小球肾炎期间形成的驼峰状致密沉积物最终通过三种假设机制溶解：失去电子密度、被足细胞内化和处理以及并入肾小球基底膜（GBM）。通过超微结构分析多形核白细胞与驼峰状沉积物的关联，我们强调了支持致密沉积物免疫复合物在白细胞活性作用下释放到循环中的假说的特征。活跃的多形核细胞通过补体激活和与NAPlr结合的纤溶酶在接触区域溶解GBM。免疫复合物从驼峰向血液循环的反向流动会在完全溶解之前留下逐渐消退、呈皱纹状的驼峰。
