Neurology (127), Bruce Carter Veterans Affairs Medical Center, 1201 NW 16th Street, Miami, FL 33125, USA.
Curr Neurol Neurosci Rep. 2012 Dec;12(6):642-54. doi: 10.1007/s11910-012-0311-6.
Though well-known as a cause of liver disease, Hepatitis C virus infection is emerging as a cause of a variety of peripheral and central nervous system disorders. The virus causes chronic persistent infection with complex immune responses in the majority of individuals. Viral infection may have the potential to generate neurological illness through direct infection of neural cells or through immune-mediated mechanisms, including enhancement of autoimmune responses. Moreover, the mainstay of antiviral treatment of hepatitis C infection, interferon-alpha, is itself associated with neurological morbidity. Thus neurologists are increasingly faced with diagnosing or even predicting a wide spectrum of neurological complications of hepatitis C infection and/or its treatment.
虽然丙型肝炎病毒感染是众所周知的肝脏疾病的病因，但它现在也逐渐成为多种周围和中枢神经系统疾病的病因。该病毒在大多数个体中引起慢性持续感染，并伴有复杂的免疫反应。病毒感染可能通过直接感染神经细胞或通过免疫介导的机制（包括增强自身免疫反应）而导致神经疾病。此外，丙型肝炎病毒感染的抗病毒治疗的主要药物干扰素-α本身也与神经发病率相关。因此，神经科医生越来越多地面临诊断甚至预测丙型肝炎感染及其治疗的广泛的神经系统并发症。
