Francescato G, Agosti M, Bedogni G, Pastò E, Melzi d'Eril G, Barassi A, Risè P, Agostoni C
Neonatology and NICU, Maternal and Child Department, Filippo Del Ponte Hospital, Varese, Italy.
Pediatr Obes. 2012 Dec;7(6):e86-9. doi: 10.1111/j.2047-6310.2012.00097.x. Epub 2012 Sep 19.
Biochemical predictors of infants' growth changes are not available.
We tested whether retinol-binding protein (RBP), docosahexaenoic acid and insulin (I) measured within 72 h from birth are associated with growth changes in infants born to mothers with gestational diabetes mellitus (GDM).
Fifty-six children, 32 born to diabetic mothers treated with insulin (GDM-I) and 24 born to diabetic mothers treated with diet (GDM-D), were evaluated at 0, 1, 3, 6 and 12 months of life.
At multivariable regression performed using generalized estimating equations, early RBP levels and maternal body mass index were associated to average weight changes and early RBP and insulin levels to average length changes, respectively. There was no difference between GDM-I and GDM-D infants.
This exploratory study suggests that early RBP levels may be a predictor of growth changes.
尚无婴儿生长变化的生化预测指标。
我们测试了出生后72小时内测得的视黄醇结合蛋白（RBP）、二十二碳六烯酸和胰岛素（I）是否与患有妊娠期糖尿病（GDM）的母亲所生婴儿的生长变化有关。
对56名儿童进行了评估，其中32名是接受胰岛素治疗的糖尿病母亲所生（GDM-I），24名是接受饮食治疗的糖尿病母亲所生（GDM-D），评估时间为出生后0、1、3、6和12个月。
在使用广义估计方程进行的多变量回归分析中，早期RBP水平和母亲体重指数分别与平均体重变化相关，早期RBP和胰岛素水平分别与平均身长变化相关。GDM-I组和GDM-D组婴儿之间没有差异。
这项探索性研究表明，早期RBP水平可能是生长变化的一个预测指标。
