Department Head and Neck Surgery, Kaiser Permanente Medical Center Walnut Creek, California, USA.
Laryngoscope. 2013 Feb;123(2):426-8. doi: 10.1002/lary.23725. Epub 2012 Sep 18.
First bite syndrome is a well-described sequelae of parapharyngeal space surgery, thought to result from sympathetic denervation of the parotid gland. We describe a case of first bite syndrome caused by an adenoid cystic carcinoma of the submandibular gland. The tumor was not clinically or radiographically apparent until 18 months after initial presentation despite repeated imaging. In patients with first bite syndrome and no surgical history, there must be high suspicion for a malignancy, which may be occult on presentation. The submandibular gland should be considered as a possible site of a lesion.
第一口综合征是咽旁间隙手术的一种常见后遗症，被认为是由于腮腺交感神经支配丧失所致。我们描述了一例由下颌下腺腺样囊性癌引起的第一口综合征。尽管进行了多次影像学检查，但在初次就诊后 18 个月，肿瘤才在临床上和影像学上显现出来。对于有第一口综合征且无手术史的患者，必须高度怀疑恶性肿瘤，即使在初次就诊时可能也不明显。下颌下腺应被视为病变的可能部位。
