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用于药物靶向的分子滤片芯片设计。

Molecular filter on-chip design for drug targeting use.

机构信息

Institute of Advanced Photonics Science, Nanotechnology Research Alliance, Universiti Teknologi Malaysia (UTM), Johor Bahru, Malaysia.

出版信息

Artif Cells Nanomed Biotechnol. 2013 Jun;41(3):178-83. doi: 10.3109/10731199.2012.715087. Epub 2012 Sep 19.

Abstract

This paper presents the use of a modified add/drop optical filter incorporating with microring resonators known as a PANDA microring resonator system which can fabricate on small chip. By using an optical tweezer, the required molecules can be trapped and moved to the required destinations at the add/drop ports. The novelty is that the stored molecules in the designed chip can transport via the optical waveguide and can also be used to form molecular filter, which is an important technique for drug delivery, drug targeting, and molecular electronics. Results have shown that the multivariable filter can be obtained by tunable trapping control.

摘要

本文提出了一种使用改进的加/ 减光滤波器结合微环谐振器的方法,称为熊猫型微环谐振器系统,可在小芯片上制造。通过使用光学镊子,可以捕获所需的分子并将其移动到加/ 减端口的所需位置。新颖之处在于,设计的芯片中存储的分子可以通过光波导传输,也可以用于形成分子滤波器,这是药物输送、药物靶向和分子电子学的重要技术。结果表明,通过可调谐捕获控制可以获得多变量滤波器。

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