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特应性哮喘患者的气道蛋白酶/抗蛋白酶失衡导致甲型流感病毒的切割和复制增加。

Airway protease/antiprotease imbalance in atopic asthmatics contributes to increased influenza A virus cleavage and replication.

出版信息

Respir Res. 2012 Sep 19;13(1):82. doi: 10.1186/1465-9921-13-82.

DOI:10.1186/1465-9921-13-82
PMID:22992220
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3489803/
Abstract

Asthmatics are more susceptible to influenza infections, yet mechanisms mediating this enhanced susceptibility are unknown. Influenza virus hemagglutinin (HA) protein binds to sialic acid residues on the host cells. HA requires cleavage to allow fusion of the viral HA with host cell membrane, which is mediated by host trypsin-like serine protease. We show data here demonstrating that the protease:antiprotease ratio is increased in the nasal mucosa of asthmatics and that these changes were associated with increased proteolytic activation of influenza. These data suggest that disruption of the protease balance in asthmatics enhances activation and infection of influenza virus.

摘要

哮喘患者更容易感染流感，但介导这种易感性增强的机制尚不清楚。流感病毒血凝素（HA）蛋白与宿主细胞上的唾液酸残基结合。HA 需要裂解才能允许病毒 HA 与宿主细胞膜融合，这是由宿主胰蛋白酶样丝氨酸蛋白酶介导的。我们在这里展示的数据表明，哮喘患者的鼻黏膜中蛋白酶：抗蛋白酶的比例增加，并且这些变化与流感的蛋白水解激活增加有关。这些数据表明，哮喘患者中蛋白酶平衡的破坏增强了流感病毒的激活和感染。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c81/3489803/c095b8c77018/1465-9921-13-82-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c81/3489803/c095b8c77018/1465-9921-13-82-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c81/3489803/c095b8c77018/1465-9921-13-82-1.jpg

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