Department of Biological Sciences, Cross River University of Technology, Calabar, Nigeria.
Parasit Vectors. 2012 Sep 19;5:203. doi: 10.1186/1756-3305-5-203.
In order to initiate a disease elimination programme for lymphatic filariasis based on mass drug administration, a proper understanding of the geographical distribution and degree of risk is essential.
An investigation of lymphatic filariasis due to Wuchereria bancrofti was carried out among 785 people in four communities of Yakurr Local Government Area of Cross River State, Nigeria between March and August, 2009. Finger prick blood smear samples collected from the subjects were examined for W. bancrofti using standard parasitological protocol. The subjects were also screened for clinical manifestations of lymphatic filariasis.
Of the 785 persons examined, 48 (6.1%) were positive for microfilariae in their thick blood smear. There was a significant difference in the prevalence of lymphatic filariasis among the various age groups (P < 0.01) although peak prevalence occurred between 41-60 years. There was no significant difference in prevalence and density with respect to sex (P > 0.05). The overall mean microfilarial density of the infected individuals was 5.6 mf/50 μl. There was a significant variation (P < 0.01) in mean microfilarial density within the communities, ranging from 4.7 to 6.4 mf/50 μl. The only clinical sign found in the study area was lymphoedema of the leg recording 2 (0.3%) prevalence.
The National Lymphatic Filariasis Elimination Programme should intervene by expanding the distribution of albendazole and ivermectin to all endemic areas including Yakurr Local Government Area of Cross River State, Nigeria.
为了启动基于大规模药物治疗的淋巴丝虫病消除计划，必须正确了解地理分布和风险程度。
2009 年 3 月至 8 月，在尼日利亚十字河州 Yakurr 地方政府区的四个社区中，对 785 人进行了班氏吴策线虫引起的淋巴丝虫病调查。从受试者中采集的指尖刺破血涂片样本，采用标准寄生虫学方案检查是否存在班氏吴策线虫。还对受试者进行了淋巴丝虫病临床症状筛查。
在检查的 785 人中，48 人（6.1%）厚血涂片中有微丝蚴阳性。虽然 41-60 岁之间的流行率最高，但不同年龄组之间的淋巴丝虫病流行率存在显著差异（P<0.01）。性别之间的流行率和密度无显著差异（P>0.05）。受感染个体的平均微丝蚴密度为 5.6 mf/50 μl。各社区之间的平均微丝蚴密度存在显著差异（P<0.01），范围为 4.7-6.4 mf/50 μl。在研究区域中发现的唯一临床体征是腿部淋巴水肿，患病率为 2（0.3%）。
国家淋巴丝虫病消除计划应通过向包括尼日利亚十字河州 Yakurr 地方政府区在内的所有流行地区扩大阿苯达唑和伊维菌素的分布来进行干预。
