Eggink Alex J
Erasmus MC, afd. Verloskunde en Gynaecologie, Rotterdam, the Netherlands.
Ned Tijdschr Geneeskd. 2012;156(38):A4924.
Spina bifida is the most common congenital birth defect involving the central nervous system. It results in central and peripheral abnormalities. Patients with severe spina bifida may have a lifelong disability with dependence on medical and social supportive care. A randomized controlled trial demonstrated that, for a selected number of patients, prenatal closure of the defect resulted in a better neurological outcome than postnatal surgical repair. Prenatal surgery of spina bifida is associated with an increased risk of preterm birth and obstetric complications and is not yet considered the standard of care in the Netherlands. In case of a prenatal diagnosis of spina bifida, the pregnant woman is entitled to full information about the possibility of prenatal treatment and to a possible referral for this.
脊柱裂是最常见的累及中枢神经系统的先天性出生缺陷。它会导致中枢和外周异常。患有严重脊柱裂的患者可能会终身残疾，依赖医疗和社会支持性护理。一项随机对照试验表明，对于部分选定患者，产前闭合缺损比产后手术修复能带来更好的神经学预后。脊柱裂的产前手术与早产和产科并发症风险增加相关，在荷兰尚未被视为标准治疗方法。如果产前诊断出脊柱裂，孕妇有权获得关于产前治疗可能性的全面信息，并有权获得为此进行的可能转诊。
