Bödvarsson A, Franzson L, Briem H
Department of Medicine, Reykjavik City Hospital, Iceland.
J Intern Med. 1990 Jan;227(1):5-9. doi: 10.1111/j.1365-2796.1990.tb00110.x.
In order to predict the outcome of patients with acute neurological symptoms at discharge, the concentration of creatine kinase isoenzyme BB (CK-BB) was determined by radioimmunoassay in the cerebrospinal fluid (CSF) of 115 consecutive patients. On admission and over the next 3 days the concentration of CK-BB was significantly increased in patients with brain death and other neurological sequelae compared with those with favourable outcome. There was a variation in time in concentrations of CK-BB between diseases causing neurological sequelae. Thus, cerebrovascular haemorrhages caused highest concentrations on admission, but cerebral ischaemia due to cardiac arrest caused highest concentrations 3 days after admission. On admission the CK-BB measurements were highly specific with high predictive value of positive result when distinguishing patients with brain death and other neurological sequelae from those without complications at discharge. However, when distinguishing patients with brain death from those with other neurological sequelae, the test was most specific and had highest predictive value of a positive result 3 days after admission.
为了预测急性神经症状患者出院时的预后情况，采用放射免疫分析法测定了115例连续患者脑脊液（CSF）中肌酸激酶同工酶BB（CK-BB）的浓度。入院时及随后3天，与预后良好的患者相比，脑死亡和其他神经后遗症患者的CK-BB浓度显著升高。导致神经后遗症的疾病之间，CK-BB浓度随时间存在差异。因此，脑血管出血在入院时导致的浓度最高，但心脏骤停所致脑缺血在入院3天后导致的浓度最高。入院时，CK-BB检测具有高度特异性，在区分出院时有无并发症的患者时，阳性结果具有较高的预测价值。然而，在区分脑死亡患者和其他神经后遗症患者时，该检测在入院3天后最具特异性，阳性结果的预测价值最高。
