Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London, WC1N 3JH, England, UK.
Pediatr Nephrol. 2013 Jul;28(7):1001-9. doi: 10.1007/s00467-012-2260-3. Epub 2012 Sep 21.
Rituximab was initially developed for the treatment of patients with B cell lymphoma but has during the last decade proven to be quite effective in treating a range of kidney diseases including lupus nephritis, nephrotic syndrome, and also in different situations before and after a renal transplant. We will here review the scientific basis for the use of rituximab in children with renal diseases and give recommendations both regarding its clinical use and need for further research.
利妥昔单抗最初是为治疗 B 细胞淋巴瘤患者而开发的，但在过去十年中，已被证明在治疗一系列肾脏疾病方面非常有效，包括狼疮性肾炎、肾病综合征，以及在肾移植前后的不同情况下。我们将在此回顾利妥昔单抗在儿童肾脏疾病中的使用的科学依据，并就其临床应用和进一步研究的必要性提出建议。
