Safadieh Layal, Dabbagh Omar
1Division of Pediatric Neurology, Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
J Child Neurol. 2013 Oct;28(10):1222-5. doi: 10.1177/0883073812456085. Epub 2012 Sep 18.
Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is a recently recognized autoimmune neurologic disorder that presents with severe neuropsychiatric symptoms in previously healthy children. A 4-year-old Lebanese girl presented with new-onset behavioral changes, orofacial dyskinesias, fluctuation in consciousness, inability to walk, and mutism. Antibodies directed against NMDA receptors were detected in the patient's serum and cerebrospinal fluid. Prompt treatment with a single course of intravenous immunoglobulin resulted in early complete recovery. This is the first case report of a Middle Eastern child affected with this condition.
抗N-甲基-D-天冬氨酸（NMDA）受体脑炎是一种最近才被认识的自身免疫性神经疾病，在以前健康的儿童中表现为严重的神经精神症状。一名4岁的黎巴嫩女孩出现了新发的行为改变、口面部运动障碍、意识波动、无法行走和缄默症。在患者的血清和脑脊液中检测到了针对NMDA受体的抗体。单次静脉注射免疫球蛋白的及时治疗导致了早期完全康复。这是中东地区受这种疾病影响的儿童的首例病例报告。
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