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风湿性疾病患者是否对大剂量糖皮质激素治疗的眼部并发症进行了适当监测?

Are ocular complications of a high-dose glucocorticoid treatment appropriately monitored in patients with rheumatic diseases?

机构信息

Division of Rheumatology, Cooper Medical Center/UMDNJ Robert Wood Johnson Medical School, Camden, NJ, USA,

出版信息

Rheumatol Int. 2013 Nov;33(11):2951-2. doi: 10.1007/s00296-012-2456-7. Epub 2012 Aug 22.

Abstract

Glucocorticoid is frequently used in treating various rheumatic conditions. However it is known to cause multiple toxicities including cataract or glaucoma. In this study, we examined whether patients with rheumatic diseases had appropriate ocular monitoring for glucocorticoid toxicities. From rheumatology clinics in South New Jersey of the USA, we retrospectively identified patients with ages between 18 and 60 years old who received a high accumulative dose of glucocorticoid, which was defined as glucocorticoid dose greater than prednisone 7.5mg/day × 6 months = 1,350 mg. We observed rheumatologists recommended eye examinations only in 14/37 (37.8 %) of patients. Family history was present for cataract in 13/37 (35.1 %) patients and for glaucoma in 6/37 (16.2 %) patients. Rheumatologists recommended eye examinations in 4/13 (30.7 %) and 0/6 (0 %) patients in each group. This study suggested that rheumatologists did not appropriately monitor ocular complications of a high dose glucocorticoid, even in patients with a positive family history.

摘要

糖皮质激素常用于治疗各种风湿性疾病。然而,它已知会引起多种毒性,包括白内障或青光眼。在这项研究中,我们检查了患有风湿性疾病的患者是否对糖皮质激素毒性进行了适当的眼部监测。我们从美国南新泽西的风湿病诊所回顾性地确定了年龄在 18 至 60 岁之间接受高累积剂量糖皮质激素的患者,这一定义为糖皮质激素剂量大于泼尼松 7.5mg/天×6 个月=1,350mg。我们观察到只有 14/37(37.8%)的患者的风湿病医生建议进行眼部检查。13/37(35.1%)的患者有白内障家族史,6/37(16.2%)的患者有青光眼家族史。在每个家族史阳性的患者中,风湿病医生建议进行眼部检查的比例分别为 4/13(30.7%)和 0/6(0%)。这项研究表明,即使在有阳性家族史的患者中,风湿病医生也没有适当监测大剂量糖皮质激素的眼部并发症。

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