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本文引用的文献

1
Two outbreaks of botulism associated with consumption of green olive paste, France, September 2011.两起因食用绿橄榄酱导致的肉毒中毒暴发，法国，2011 年 9 月。
Euro Surveill. 2011 Dec 8;16(49):20035. doi: 10.2807/ese.16.49.20035-en.
2
One collective case of type A foodborne botulism in Corsica.科西嘉岛发生一起 A 型食源性肉毒中毒聚集性病例。
Clin Toxicol (Phila). 2011 Oct;49(8):752-4. doi: 10.3109/15563650.2011.606222.
3
MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods.MEGA5：用于最大似然法、进化距离法和最大简约法的分子进化遗传学分析。
Mol Biol Evol. 2011 Oct;28(10):2731-9. doi: 10.1093/molbev/msr121. Epub 2011 May 4.
4
A label-free biosensor assay for botulinum neurotoxin B in food and human serum.一种用于食品和人血清中肉毒神经毒素 B 的无标记生物传感器分析方法。
Anal Biochem. 2011 Mar 15;410(2):281-8. doi: 10.1016/j.ab.2010.11.045. Epub 2010 Dec 4.
5
Characterization of botulinum neurotoxin type A neutralizing monoclonal antibodies and influence of their half-lives on therapeutic activity.A型肉毒毒素中和单克隆抗体的鉴定及其半衰期对治疗活性的影响。
PLoS One. 2010 Aug 26;5(8):e12416. doi: 10.1371/journal.pone.0012416.
6
Extraction and inhibition of enzymatic activity of botulinum neurotoxins/A1, /A2, and /A3 by a panel of monoclonal anti-BoNT/A antibodies.一组抗肉毒杆菌神经毒素/A单克隆抗体对肉毒杆菌神经毒素/A1、/A2和/A3的提取及酶活性抑制作用
PLoS One. 2009;4(4):e5355. doi: 10.1371/journal.pone.0005355. Epub 2009 Apr 28.
7
Independent evolution of neurotoxin and flagellar genetic loci in proteolytic Clostridium botulinum.肉毒梭菌中神经毒素和鞭毛基因位点的独立进化
BMC Genomics. 2009 Mar 19;10:115. doi: 10.1186/1471-2164-10-115.
8
Two severe cases of botulism associated with industrially produced chicken enchiladas, France, August 2008.2008年8月，法国出现两例与工业化生产的鸡肉玉米卷相关的严重肉毒中毒病例。
Euro Surveill. 2008 Sep 11;13(37):18978. doi: 10.2807/ese.13.37.18978-en.
9
Botulism diagnostics: from clinical symptoms to in vitro assays.肉毒中毒的诊断：从临床症状到体外检测
Crit Rev Microbiol. 2007 Apr-Jun;33(2):109-25. doi: 10.1080/10408410701364562.
10
Detection of functional ricin by immunoaffinity and liquid chromatography-tandem mass spectrometry.通过免疫亲和及液相色谱-串联质谱法检测功能性蓖麻毒素
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质谱法检测法国两起 A 型肉毒中毒爆发期间患者血清中的毒素。

Toxin detection in patients' sera by mass spectrometry during two outbreaks of type A Botulism in France.

机构信息

Institut Pasteur, Unité des Bactéries Anaérobies et Toxines, Paris, France.

出版信息

J Clin Microbiol. 2012 Dec;50(12):4091-4. doi: 10.1128/JCM.02392-12. Epub 2012 Sep 19.

DOI:10.1128/JCM.02392-12
PMID:22993181
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3502950/
Abstract

In two outbreaks of food-borne botulism in France, Clostridium botulinum type A was isolated and characterized from incriminated foods. Botulinum neurotoxin type A was detected in the patients' sera by mouse bioassay and in vitro endopeptidase assay with an immunocapture step and identification of the cleavage products by mass spectrometry.

摘要

在法国的两起因食物传播的肉毒中毒暴发事件中，从可疑食物中分离并鉴定出 A 型肉毒梭菌。通过小鼠生物测定法和体外内切酶测定法（免疫捕获步骤），从患者血清中检测到 A 型肉毒神经毒素，并通过质谱法鉴定裂解产物。