Department of Neurosurgery, Mount Sinai School of Medicine, New York, New York, USA.
J Neurointerv Surg. 2013 Nov;5(6):573-6. doi: 10.1136/neurintsurg-2012-010483. Epub 2012 Sep 19.
The Penumbra Coil 400 System (PC 400) is the newly introduced platinum coil system designed specifically to enhance filling efficiency by increasing coil diameter. Our goal was to study the packing and treatment advantage of the PC 400's unique geometric configuration compared with conventional coils (controls).
16 aneurysms embolized with the PC 400 in 2011 were compared with 79 equally matched aneurysms embolized with conventional coils from 2004 to 2011. Primary outcomes assessed were acute packing density, embolization time, and the number of coils required for aneurysm occlusion.
Aneurysm embolization with the PC 400 achieved a higher packing density (36.8% vs 28.1%; p<0.005) and with fewer coils (an average of 3.9 vs 6.1 coils per aneurysm; p<0.05). In addition, the total procedural time for the subjects treated with the PC 400 was significantly less (45.7 vs 64.1 min; p<0.05). There were no procedural complications associated with the PC 400.
Compared with conventional coils, the PC 400 is more efficient in the embolization of cerebral aneurysms, achieving greater packing density with fewer coils and less time without compromising safety.
Penumbra Coil 400 系统（PC 400）是新引入的铂金线圈系统，旨在通过增加线圈直径来提高填充效率。我们的目标是研究 PC 400 独特的几何结构在包装和治疗方面与传统线圈（对照组）相比的优势。
2011 年使用 PC 400 栓塞的 16 个动脉瘤与 2004 年至 2011 年使用传统线圈同等匹配的 79 个动脉瘤进行比较。评估的主要结果是急性包装密度、栓塞时间和用于闭塞动脉瘤所需的线圈数量。
与传统线圈相比，PC 400 栓塞的动脉瘤具有更高的包装密度（36.8%比 28.1%；p<0.005）和更少的线圈（平均每个动脉瘤使用 3.9 个比 6.1 个线圈；p<0.05）。此外，使用 PC 400 治疗的患者的总手术时间明显更短（45.7 分钟比 64.1 分钟；p<0.05）。PC 400 没有与程序相关的并发症。
与传统线圈相比，PC 400 更有效地栓塞脑动脉瘤，用更少的线圈达到更高的包装密度，并且时间更短，同时不影响安全性。
