PAR-1 多态性与中国人幽门螺杆菌相关性胃癌风险。
PAR-1 polymorphisms and risk of Helicobacter pylori-related gastric cancer in a Chinese population.
机构信息
School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, Australia.
出版信息
Anticancer Res. 2012 Sep;32(9):3715-21.
BACKGROUND
PAR-1 has been involved in inflammation of the gastrointestinal tract, tumour cell growth and invasion of gastric carcinoma cells. Thus, we aimed at determining, for the first time, the association between PAR-1 - 506 ins/del and -IVSn-14 A/T and risk of Helicobacter pylori-related gastric cancer (GC) in an ethnic Chinese population.
MATERIALS AND METHODS
A case-control study comprising of 225 ethnic Chinese individuals (77 non-cardia GC cases and 148 controls with functional dyspepsia) was conducted. PAR-1 IVSn-14 A/T and 506 ins/del were genotyped by means of real-time PCR and MALDI-TOF mass spectrometry, respectively.
RESULTS
H. pylori infection, male gender and the PAR-1 IVSn-14 TT genotype increased GC risk (OR:3.15, 95% CI:1.54-6.45, OR:2.44, 95% CI:1.35-4.42 and OR:2.58, 95% CI:1.09-6.13, respectively). PAR-1 -506 ins/del did not provide significant results.
CONCLUSION
PAR-1 IVSn-14 T allele is a risk factor for H. pylori-related GC in ethnic Chinese subjects. PAR-1 -506 ins/del polymorphism is not involved in gastric carcinogenesis.
背景
PAR-1 参与了胃肠道炎症、肿瘤细胞生长和胃癌细胞的侵袭。因此，我们旨在首次确定 PAR-1-506ins/del 和-IVSn-14A/T 与幽门螺杆菌相关胃癌（GC）风险之间的关联在汉族人群中。
材料和方法
进行了一项病例对照研究，包括 225 名汉族个体（77 名非贲门 GC 病例和 148 名功能性消化不良对照）。通过实时 PCR 和 MALDI-TOF 质谱法分别对 PAR-1-IVSn-14A/T 和 506ins/del 进行基因分型。
结果
幽门螺杆菌感染、男性和 PAR-1-IVSn-14TT 基因型增加了 GC 风险（OR：3.15，95%CI：1.54-6.45，OR：2.44，95%CI：1.35-4.42 和 OR：2.58，95%CI：1.09-6.13，分别）。PAR-1-506ins/del 没有提供显著结果。
结论
PAR-1-IVSn-14T 等位基因是汉族人群中与幽门螺杆菌相关 GC 的危险因素。PAR-1-506ins/del 多态性不参与胃癌的发生。
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