Association between Polymorphism of Genes , , , and and Susceptibility to Non-Small Cell Lung Cancer in the Brazilian Amazon.

Non-small cell lung cancer (NSCLC) accounts for the vast majority of cases of lung neoplasms. It is formed in multiple stages, with interactions between environmental risk factors and individual genetic susceptibility and with genes involved in the immune and inflammatory response paths, cell or genome stability, and metabolism, among others. Our objective was to evaluate the association between five genetic variants (, , , and ) and the development of NSCLC in the Brazilian Amazon. The study included 263 individuals with and without lung cancer. The samples were analyzed for the genetic variants of (rs28362491), (rs11267092), (rs17878362), (rs3783553), and (INDEL 45-bp), which were genotyped in PCR, followed by an analysis of the fragments, in which we applied a previously developed set of informative ancestral markers. We used a logistic regression model to identify differences in the allele and the genotypic frequencies among individuals and their association with NSCLC. The variables of gender, age, and smoking were controlled in the multivariate analysis to prevent confusion by association. The individuals that were homozygous for the Del/Del of polymorphism (rs28362491) ( = 0.018; OR = 0.332) demonstrate a significant association with NSCLC, which was similar to that observed in the variants of (rs11267092) ( = 0.023; OR = 0.471) and (rs17878362) ( = 0.041; OR = 0.510). Moreover, the individuals with the Ins/Ins genotype of polymorphism (rs3783553) demonstrated greater risk for NSCLC ( = 0.033; OR = 2.002), as did the volunteers with the Del/Del of (INDEL 45-bp) ( = 0.031; OR = 2.031). The five polymorphisms investigated can contribute towards NSCLC susceptibility in the population of the Brazilian Amazon.