基质金属蛋白酶-1 多态性与 COPD 和肺癌风险及肺癌患者生存的相关性。
Association of matrix metalloproteinase-1 polymorphisms with risk of COPD and lung cancer and survival in lung cancer.
机构信息
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
出版信息
Anticancer Res. 2012 Sep;32(9):3917-22.
BACKGROUND
The primary risk factor for chronic obstructive pulmonary disease (COPD) and non-small cell lung cancer (NSCLC) is cigarette smoking but shared susceptibility factors, such as variations in the matrix metalloproteinase-1 (MMP1) gene, may also underlie both diseases.
MATERIALS AND METHODS
Cases with prevalent COPD (n=167), incident NSCLC (n=242), or prevalent COPD plus incident NSCLC (n=128) were compared to disease-free controls (n=338) to assess six MMP1 polymorphisms. The association between these polymorphisms and survival in NSCLC was also evaluated.
RESULTS
Rs11292517 among African-Americans [odds ratio (OR)=5.48, 95% confidence interval (CI)=1.17-25.72] and rs2071230 among Caucasians (OR=2.51, 95% CI=1.09-5.77) appeared to be associated with NSCLC risk in the presence of COPD. Rs470558 appeared to be associated with survival in NSCLC among African-Americans (hazard ratio=3.94; 95%CI=1.14-13.63). No associations remained after adjusting for multiple comparisons.
CONCLUSION
Polymorphisms in MMP1 were not consistently associated with prevalent COPD or incident NSCLC nor with survival in NSCLC.
背景
慢性阻塞性肺疾病（COPD）和非小细胞肺癌（NSCLC）的主要危险因素是吸烟，但基质金属蛋白酶-1（MMP1）基因等共同的易感因素也可能是这两种疾病的基础。
材料与方法
将患有慢性阻塞性肺病（COPD）（n=167）、新发 NSCLC（n=242）或 COPD 合并 NSCLC（n=128）的病例与无疾病对照（n=338）进行比较，以评估 MMP1 的 6 种基因多态性。还评估了这些多态性与 NSCLC 患者生存的关系。
结果
在 COPD 存在的情况下，非洲裔美国人中的 rs11292517（比值比[OR]=5.48，95%置信区间[CI]=1.17-25.72）和高加索人中的 rs2071230（OR=2.51，95%CI=1.09-5.77）似乎与 NSCLC 风险相关。rs470558 似乎与非洲裔美国人 NSCLC 患者的生存相关（危险比[HR]=3.94；95%CI=1.14-13.63）。在进行多次比较调整后，没有关联仍然存在。
结论
MMP1 基因多态性与 COPD 的发生或 NSCLC 的发生以及 NSCLC 患者的生存没有一致的相关性。
Zotero 插件