基质金属蛋白酶9基因多态性与慢性阻塞性肺疾病易感性的Meta分析
Genetic polymorphism of matrix metalloproteinase 9 and susceptibility to chronic obstructive pulmonary disease: A meta-analysis.
作者信息
Yang Xiaoping, Yu Yuanyuan, Wang Yong, Jiang Wen, Jiang Wenqing, Yin Bin
机构信息
Qingdao Hospital of Traditional Chinese Medicine (Haici Hospital), Department 2 of Respiratory and Critical Care (Lung disease) Center, Qingdao, China.
Qingdao Hospital of Traditional Chinese Medicine (Haici Hospital), Department of Anesthesiology, Qingdao, China.
出版信息
J Med Biochem. 2022 Jul 29;41(3):263-274. doi: 10.5937/jomb0-34155.
BACKGROUND
To systematically analyze the influence of genetic polymorphisms of matrix metalloproteinase 9 (MMP9) on susceptibility to chronic obstructive pulmonary disease (COPD).
METHODS
Relevant literatures reporting MMP9 and susceptibility to COPD in PubMed, Web of Science, VIP, Wanfang and CNKI databases were searched using the key words "matrix metalloproteinases 9/MMP9, COPD/chronic obstructive pulmonary disease". Data of eligible literatures were extracted and analyzed for the odds ratio (OR) and corresponding 95% CI.
RESULTS
A total of 16 independent studies reporting MMP9-1562C/T and COPD patients were enrolled and analyzed. None of the genetic models revealed the relationship between MMP9-1562C/T and susceptibility to COPD. Subgroup analyses identified lower risk of COPD in Chinese population carrying the TT genotype for theMMP9 rs3918242 relative to those carrying CT and CC genotypes (P=0.03, OR=0.67, 95% CI=0.46-0.97).
CONCLUSIONS
Chinese population carrying the TT genotype for the MMP-9 rs3918242 present lower susceptibility to COPD relative to those carrying CT and CC genotypes.
背景
系统分析基质金属蛋白酶9（MMP9）基因多态性对慢性阻塞性肺疾病（COPD）易感性的影响。
方法
使用关键词“基质金属蛋白酶9/MMP9，COPD/慢性阻塞性肺疾病”在PubMed、Web of Science、维普、万方和中国知网数据库中检索报道MMP9与COPD易感性的相关文献。提取符合条件文献的数据并分析比值比（OR）及相应的95%可信区间（CI）。
结果
共纳入并分析了16项报道MMP9 - 1562C/T与COPD患者的独立研究。所有遗传模型均未显示MMP9 - 1562C/T与COPD易感性之间的关系。亚组分析发现，携带MMP9 rs3918242的TT基因型的中国人群患COPD的风险低于携带CT和CC基因型的人群（P = 0.03，OR = 0.67，95%CI = 0.46 - 0.97）。
结论
携带MMP - 9 rs3918242的TT基因型的中国人群相对于携带CT和CC基因型的人群对COPD的易感性较低。
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