立体定向体部放射治疗伴慢性呼吸功能不全需家庭氧疗的Ⅰ期非小细胞肺癌患者。
Stereotactic body radiation therapy for stage I non-small cell lung cancer patients with chronic respiratory insufficiency requiring domiciliary oxygen therapy.
机构信息
Department of Heavy Particle Therapy and Radiation Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
出版信息
Anticancer Res. 2012 Sep;32(9):4041-4.
BACKGROUND
The efficacy of stereotactic body radiation therapy (SBRT) for patients treated with domiciliary oxygen therapy is not well-known.
PATIENTS AND METHODS
We collected the clinical records of 15 patients with chronic respiratory insufficiency requiring domiciliary oxygen therapy at 1-3 l/min who were treated with SBRT for stage I non-small cell lung cancer. All patients were fixed with a thermoplastic body cast system. SBRT was given in 7-8 fields with an isocenter dose of 40-60 Gy in 4-10 fractions (median, 48 Gy in 4 fractions).
RESULTS
The overall 2-year and 5-year survival rates for all patients were 67.4% and 34.7%, while the disease-specific 2-year and 5-year survival rates were 90.0% and 72.0%, respectively. Pulmonary adverse effects were mild in the majority of the patients, although two patients had grade 2 radiation pneumonitis. The oxygen flow required increased slightly at follow-up periods greater than one year, but was still at an acceptable level.
CONCLUSION
SBRT was feasible for patients requiring domiciliary oxygen therapy.
背景
接受家庭氧疗的患者行立体定向体部放射治疗（SBRT）的疗效尚不清楚。
患者与方法
我们收集了 15 例患有慢性呼吸功能不全、需要 1-3L/min 家庭氧疗的患者的临床记录，这些患者因Ⅰ期非小细胞肺癌接受 SBRT 治疗。所有患者均采用热塑体模系统固定。SBRT 采用 7-8 野照射，等中心剂量为 40-60Gy，分 4-10 次（中位数：4 次，48Gy）。
结果
所有患者的总 2 年和 5 年生存率分别为 67.4%和 34.7%，疾病特异性 2 年和 5 年生存率分别为 90.0%和 72.0%。大多数患者的肺部不良反应较轻，但有 2 例患者出现 2 级放射性肺炎。在随访 1 年以上的时间里，氧气流量略有增加，但仍处于可接受的水平。
结论
SBRT 对于需要家庭氧疗的患者是可行的。
Zotero 插件