Nofzinger E A, Schmidt H S
Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213.
J Nerv Ment Dis. 1990 Feb;178(2):90-5. doi: 10.1097/00005053-199002000-00003.
Diabetic impotence is generally presumed to be secondary to peripheral abnormalities of the vascular or autonomic nervous system, although central nervous control of the autonomic nervous system has not previously been studied. Measures of rapid eye movement (REM) sleep as potential indicators of central autonomic dysfunction were studied along with sleep-related tumescence for 10 impotent diabetics, nine psychogenically impotent men, and 10 men whose impotence was secondary to pelvic trauma. Low REM density was found in the diabetics with REM density correlating with measures of tumescence. These results suggest that central autonomic dysfunction may be a contributing factor in the impotence of diabetic men. A metabolic disturbance in the central nervous system of diabetics which might alter both sleep and autonomic nervous system activity is proposed to explain these results and may help in the understanding of other observed abnormalities in both the sleep and autonomic dysfunction of diabetics.
糖尿病性阳痿一般被认为是继发于血管或自主神经系统的外周异常，尽管此前尚未对自主神经系统的中枢神经控制进行研究。对10例患阳痿的糖尿病患者、9例心因性阳痿男性以及10例因盆腔创伤继发阳痿的男性，研究了快速眼动（REM）睡眠指标作为中枢自主神经功能障碍潜在指标的情况，并研究了与睡眠相关的阴茎勃起。在糖尿病患者中发现快速眼动密度较低，且快速眼动密度与阴茎勃起指标相关。这些结果表明，中枢自主神经功能障碍可能是糖尿病男性阳痿的一个促成因素。有人提出糖尿病患者中枢神经系统的代谢紊乱可能会改变睡眠和自主神经系统活动，以此来解释这些结果，这可能有助于理解糖尿病患者睡眠和自主神经功能障碍中观察到的其他异常情况。
