Chakravarthi Srikumar, Thani P M, Yang David Low Wee, Husin Linda Tjoa, Lee Nagaraja
Departments of Pathology.
Exp Ther Med. 2010 Mar;1(2):391-393. doi: 10.3892/etm_00000061. Epub 2010 Mar 1.
Apoptosis is a form of programmed cell death necessary for the regulation of the size of organs in adult life. Disruption of apoptotic pathways has been suggested as an important regulatory mechanism in prostatic tumours. The aim of this study was to examine the expression of apoptosis-regulating genes bcl-2 and p53 using immunohistochemistry, and the Gleason score in core needle biopsy specimens of prostate adenocarcinoma. We studied bcl-2 and p53 expression in 30 cases of low-, 30 cases of intermediate- and 20 cases of high-grade prostate adenocarcinoma. Overexpression of bcl-2 and p53 were noted in 54 and 61 of 80 patients (67.5 and 76.25%), respectively. The statistical analysis of the present data suggested that there is significant relation between p53 and bcl-2 expression, and Gleason score in prostate cancer. Thus, immunohistochemistry is a useful investigative parameter in assessing apoptosis to analyse the prognosis of prostatic tumours.
细胞凋亡是一种程序性细胞死亡形式，对成年期器官大小的调节至关重要。凋亡途径的破坏被认为是前列腺肿瘤的一种重要调节机制。本研究的目的是利用免疫组织化学检测凋亡调节基因bcl-2和p53的表达，以及前列腺腺癌粗针活检标本中的Gleason评分。我们研究了30例低级别、30例中级别和20例高级别前列腺腺癌中bcl-2和p53的表达。80例患者中分别有54例（67.5%）和61例（76.25%）出现bcl-2和p53的过表达。对当前数据的统计分析表明，前列腺癌中p53和bcl-2的表达与Gleason评分之间存在显著相关性。因此，免疫组织化学是评估细胞凋亡以分析前列腺肿瘤预后的一个有用的研究参数。
